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Entirely, our facts give evidence to the probable of combining CX-5461 and PARPi for strengthening the therapy of HR-deficient HGSOC. We exhibit that CX-5461 improves the synthetic lethal interaction of PARPi with HRD and clearly exhibit that CX-5461 has a distinct mechanism of motion to PARPi. Importantly, we characterised BRCA-mutated and MYC tar